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研究業績

研究について

私たちの研究室では、糖尿病患者さんの予後改善を目的として、糖尿病の病態・合併症・治療に関する様々な研究・調査を行っています。

福岡県糖尿病患者データベース研究(Fukuoka Diabetes Registry : FDR)は、2008年に開始した前向きゲノムコホート研究で、大規模データベースを構築することで日本人糖尿病患者の管理の実態を明らかにし、糖尿病や合併症治療の進歩、発展に寄与するエビデンスを発信し、糖尿病患者の予後を改善させることを理念としています。5131名の患者さんが登録されており、治療の実態調査(食事療法、身体活動、うつ状態、合併症)、および追跡調査のデータ(脳卒中、心臓病、腎臓病、悪性腫瘍などの合併症)を解析することで、糖尿病の原因・病態の解明や糖尿病治療の有効性の評価を行っています。また、ゲノム情報を用いた遺伝子解析研究も行っており、追跡調査は現在も進行中です。

その他、病態解明が困難であった症例の報告、国際的な大規模臨床試験への貢献や、メタアナリシスの発表等を通じて、糖尿病学を中心とした医学の発展に貢献しています。

私たちの研究室から発表された論文、総説、症例報告などを以下にお示しします。

業績

2022

論文発表
  1. Iwase M, Ide H, Ohkuma T, Fujii H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. Incidence of end-stage renal disease and risk factors for progression of renal dysfunction in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. Clin Exp Nephrol 2022;26:122-131
  2. Ide H, Iwase M, Ohkuma T, Fujii H, Komorita Y, Oku Y, Higashi T, Yoshinari M, Nakamura U, Kitazono T. Usefulness of urinary tubule injury markers for predicting progression of renal dysfunction in patients with type 2 diabetes and albuminuria: The Fukuoka Diabetes Registry. Diabetes Res Clin Pract 2022;186:109840
  3. Komorita Y, Ohkuma T, Iwase M, Fujii H, Ide H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T. Relationship of coffee consumption with a decline in kidney function among patients with type 2 diabetes: The Fukuoka Diabetes Registry. J Diabetes Investig 2022;13:1030-1038
  4. Ohkuma T, Harris K, Cooper M, Grobbee DE, Hamet P, Harrap S, Mancia G, Marre M, Patel A, Rodgers A, Williams B, Woodward M, Chalmers J. Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality: Results from a Randomized Controlled Trial of ACE Inhibitors. Clin J Am Soc Nephrol 2022;17:1139-1149
  5. Komorita Y, Minami M, Maeda Y, Kishita R, Ohkuma T, Kitazono T. Onset of type 1 diabetes during bone growth period is associated with increased prevalence of bone fracture: A post-hoc analysis of a cross-sectional study. J Diabetes Investig 2022;13:2101-2102
  6. Seki M, Nakano T, Tanaka S, Matsukuma Y, Funakoshi K, Ohkuma T, Kitazono T. Design and methods of an open-label, randomized controlled trial to evaluate the effect of pemafibrate on proteinuria in CKD patients (PROFIT-CKD). Clin Exp Nephrol 2023;in press
  7. 原規子, 平田詩乃, 高木可南子, 於久祐太郎, 牟田大毅, 井手均, 岩瀬正典, 大隈俊明, 北園孝成. HLA-DRB1*04:04を有した88歳男性のインスリン自己免疫症候群(平田病)の1例. 糖尿病 65: 312-318,2022
受賞歴
  1. 牛乳乳製品健康科学学術研究 2020年度最優秀賞 (大隈俊明)
  2. 令和4年度 九州大学第二内科同門会尾前賞 (井手均)
  3. 第338回 日本内科学会九州地方会 専攻医賞 (大村一華)

2021

論文発表
  1. Iwase M, Komorita Y, Ohkuma T, Fujii H, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. Incidence of stroke and its association with glycemic control and lifestyle in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. Diabetes Res Clin Pract 2021;172:108518
  2. Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Oshiro A, Nakamura U, Kitazono T. Constipation and diabetic kidney disease: The Fukuoka Diabetes Registry. Clin Exp Nephrol 2021;25:1247-1254
  3. Ohkuma T, Iwase M, Fujii H, Ide H, Komorita Y, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. Defecation frequency and glycemic control in patients with diabetes: The Fukuoka Diabetes Registry. J Diabetes Complications 2021;35:107751
  4. Komorita Y, Ohkuma T, Iwase M, Fujii H, Oku Y, Higashi T, Oshiro A, Sakamoto W, Yoshinari M, Nakamura U, Kitazono T. Polypharmacy and bone fracture risk in patients with type 2 diabetes: The Fukuoka Diabetes Registry. Diabetes Res Clin Pract 2021;181:109097
  5. Komorita Y, Minami M, Maeda Y, Yoshioka R, Ohkuma T, Kitazono T. Prevalence of bone fracture and its association with severe hypoglycemia in Japanese patients with type 1 diabetes. BMJ Open Diabetes Res Care 2021;9:e002009
  6. Yoshinari M, Hirakawa Y, Hata J, Higashioka M, Honda T, Yoshida D, Mukai N, Nakamura U, Kitazono T, Ninomiya T. Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study. Diabetologia 2021;64:1775-1784
  7. Hisadome Y, Mei T, Noguchi H, Ohkuma T, Sato Y, Kaku K, Okabe Y, Nakamura M. Safety and Efficacy of Sodium-glucose Cotransporter 2 Inhibitors in Kidney Transplant Recipients With Pretransplant Type 2 Diabetes Mellitus: A Retrospective, Single-center, Inverse Probability of Treatment Weighting Analysis of 85 Transplant Patients. Transplant Direct 2021;7:e772
  8. Ohkuma T, Chalmers J, Cooper M, Hamet P, Harrap S, Marre M, Mancia G, Poulter N, Woodward M. The comparative effects of intensive glucose lowering in diabetes patients aged below or above 65 years: Results from the ADVANCE trial. Diabetes Obes Metab 2021;23:1292-1300
  9. Neuen BL, Ohkuma T, Neal B, Matthews DR, de Zeeuw D, Mahaffey KW, Fulcher G, Blais J, Li Q, Jardine MJ, Perkovic V, Wheeler DC. Relative and Absolute Risk Reductions in Cardiovascular and Kidney Outcomes With Canagliflozin Across KDIGO Risk Categories: Findings From the CANVAS Program. Am J Kidney Dis 2021;77:23-34.e21
  10. Neuen BL, Weldegiorgis M, Herrington WG, Ohkuma T, Smith M, Woodward M. Changes in GFR and Albuminuria in Routine Clinical Practice and the Risk of Kidney Disease Progression. Am J Kidney Dis 2021;78:350-360.e351
  11. Oshiro A, Ohkuma T, Sakamoto W, Komorita Y, Oku Y, Hirakawa Y, Kitazono T. An adult patient with permanent neonatal diabetes successfully discontinued insulin therapy after initiating sitagliptin added to sulphonylurea. Diabetes Obes Metab 2021;23:1213-1214
  12. 宮本美知子,松村潔,大隈俊明. 慢性期病院における高齢患者のポリファーマシ―の実態. 日本慢性期医療協会誌 JMC 29: 92-100, 2021
  13. 小森田祐二,大隈俊明,岩瀬正典.糖尿病患者における骨折のリスク因子と予後に関する疫学研究.BIO Clinica 36 (8): 789-793, 2021
  14. 小森田祐二,大隈俊明,岩瀬正典.糖尿病患者における骨折のリスク因子と予後について―福岡県糖尿病患者データベース研究(FDR)を中心に.地域ケアリング 23 (14): 70-74, 2021
受賞歴
  1. 2021 AJKD Editors’ Choice Award (Ohkuma T, et al)
  2. 第18回 1型糖尿病研究会 若手研究奨励賞 (小森田 祐二)
  3. 第334回 日本内科学会九州地方会 専攻医賞 (坂本知子)

2020

論文発表
  1. Iwase M, Komorita Y, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. Incidence of severe hypoglycemia and its association with serum adiponectin in Japanese patients with type 1 and insulin-treated type 2 diabetes: The Fukuoka Diabetes Registry. J Diabetes Investig 2020;11:1258-1264
  2. Komorita Y, Iwase M, Idewaki Y, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Murao-Kimura A, Oku Y, Nakamura U, Kitazono T. Impact of hip fracture on all-cause mortality in Japanese patients with type 2 diabetes mellitus: The Fukuoka Diabetes Registry. J Diabetes Investig 2020;11:62-69
  3. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Yoshinari M, Oku Y, Nakamura U, Kitazono T. Both hypo- and hyperglycaemia are associated with increased fracture risk in Japanese people with type 2 diabetes: the Fukuoka Diabetes Registry. Diabet Med 2020;37:838-847
  4. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. Additive effects of green tea and coffee on all-cause mortality in patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. BMJ Open Diabetes Res Care 2020;8:e001252
  5. Ohkuma T, Peters SAE, Jun M, Harrap S, Cooper M, Hamet P, Poulter N, Chalmers J, Woodward M. Sex-specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: The ADVANCE-ON study. Diabetes Obes Metab 2020;22:1818-1826
  6. Ohkuma T, Van Gaal L, Shaw W, Mahaffey KW, de Zeeuw D, Matthews DR, Perkovic V, Neal B. Clinical outcomes with canagliflozin according to baseline body mass index: results from post hoc analyses of the CANVAS Program. Diabetes Obes Metab 2020;22:530-539
  7. Ohkuma T, Zoungas S, Jun M, Lisheng L, Mancia G, Marre M, Rodgers A, Williams B, Woodward M, Chalmers J. Intensive glucose-lowering and the risk of vascular events and premature death in patients with decreased kidney function: The ADVANCE trial. Diabetes Obes Metab 2020;22:452-457
  8. Tian J, Ohkuma T, Cooper M, Harrap S, Mancia G, Poulter N, Wang JG, Zoungas S, Woodward M, Chalmers J. Effects of Intensive Glycemic Control on Clinical Outcomes Among Patients With Type 2 Diabetes With Different Levels of Cardiovascular Risk and Hemoglobin A(1c) in the ADVANCE Trial. Diabetes Care 2020;43:1293-1299
  9. Lee AK, Woodward M, Wang D, Ohkuma T, Warren B, Sharrett AR, Williams B, Marre M, Hamet P, Harrap S, McEvoy JW, Chalmers J, Selvin E. The Risks of Cardiovascular Disease and Mortality Following Weight Change in Adults with Diabetes: Results from ADVANCE. J Clin Endocrinol Metab 2020;105:152-162
  10. Oshima M, Neal B, Toyama T, Ohkuma T, Li Q, de Zeeuw D, Heerspink HJL, Mahaffey KW, Fulcher G, Canovatchel W, Matthews DR, Perkovic V. Different eGFR Decline Thresholds and Renal Effects of Canagliflozin: Data from the CANVAS Program. J Am Soc Nephrol 2020;31:2446-2456
  11. Rahimi K, Nazarzadeh M, Pinho-Gomes AC, Woodward M, Salimi-Khorshidi G, Ohkuma T, Fitzpatrick R, Tarassenko L, Denis M, Cleland J. Home monitoring with technology-supported management in chronic heart failure: a randomised trial. Heart 2020;106:1573-1578
  12. Lee CM, Woodward M, Batty GD, Beiser AS, Bell S, Berr C, Bjertness E, Chalmers J, Clarke R, Dartigues JF, Davis-Plourde K, Debette S, Di Angelantonio E, Feart C, Frikke-Schmidt R, Gregson J, Haan MN, Hassing LB, Hayden KM, Hoevenaar-Blom MP, Kaprio J, Kivimaki M, Lappas G, Larson EB, LeBlanc ES, Lee A, Lui LY, Moll van Charante EP, Ninomiya T, Nordestgaard LT, Ohara T, Ohkuma T, Palviainen T, Peres K, Peters R, Qizilbash N, Richard E, Rosengren A, Seshadri S, Shipley M, Singh-Manoux A, Strand BH, van Gool WA, Vuoksimaa E, Yaffe K, Huxley RR. Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta-analysis consisting 2.8 million adults with 57 294 cases of dementia. Obes Rev 2020;21:e12989
  13. Tomiyama H, Vlachopoulos C, Xaplanteris P, Nakano H, Shiina K, Ishizu T, Kohro T, Higashi Y, Takase B, Suzuki T, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Tanaka A, Maemura K, Ohya Y, Furukawa T, Ito H, Ohkuma T, Ninomiya T, Chikamori T, Yamashina A, Ueda SI. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. Hypertens Res 2020;43:1284-1292
  14. Sato Y, Nunoi K, Kaku K, Yoshida A, Suganami H. Basal insulin secretion capacity predicts the initial response and maximum levels of beta-hydroxybutyrate during therapy with the sodium-glucose co-transporter-2 inhibitor tofogliflozin, in relation to weight loss. Diabetes Obes Metab 2020;22:222-230
  15. Nakao T, Takeishi C, Nunoi K, Matsuishi T, Okamura H, Sato Y, Uchizono Y, Mizuno M, Yokobori Y, Shimizu Y. Development of the Daily Time Management Scale for Use by Working People with Type 2 Diabetes. Jpn J Nurs Sci 2020;17:e12307
  16. 小森田祐二,大星博明
    第III章 1 糖尿病
    看護で教える最新の口腔ケア第1版,大道学館出版部; 50-53, 2020
受賞歴
  1. 第12回福岡県医学会賞奨励賞 (小森田祐二)

2019

論文発表
  1. Iwase M, Fujii H, Idewaki Y, Nakamura U, Ohkuma T, Ide H, Komorita Y, Jodai-Kitamura T, Yoshinari M, Kitazono T. Prospective study of cancer in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetol Int 2019;10:260-267
  2. Ohkuma T, Komorita Y, Peters SAE, Woodward M. Diabetes as a risk factor for heart failure in women and men: a systematic review and meta-analysis of 47 cohorts including 12 million individuals. Diabetologia 2019;62:1550-1560
  3. Ohkuma T, Jun M, Rodgers A, Cooper ME, Glasziou P, Hamet P, Harrap S, Mancia G, Marre M, Neal B, Perkovic V, Poulter N, Williams B, Zoungas S, Chalmers J, Woodward M. Acute Increases in Serum Creatinine After Starting Angiotensin-Converting Enzyme Inhibitor-Based Therapy and Effects of its Continuation on Major Clinical Outcomes in Type 2 Diabetes Mellitus. Hypertension 2019;73:84-91
  4. Ohkuma T, Jun M, Chalmers J, Cooper ME, Hamet P, Harrap S, Zoungas S, Perkovic V, Woodward M. Combination of Changes in Estimated GFR and Albuminuria and the Risk of Major Clinical Outcomes. Clin J Am Soc Nephrol 2019;14:862-872
  5. Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A. Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention. Hypertension 2019;73:508-513
  6. Tomiyama H, Ohkuma T, Ninomiya T, Nakano H, Matsumoto C, Avolio A, Kohro T, Higashi Y, Maruhashi T, Takase B, Suzuki T, Ishizu T, Ueda S, Yamazaki T, Furumoto T, Kario K, Inoue T, Koba S, Takemoto Y, Hano T, Sata M, Ishibashi Y, Node K, Maemura K, Ohya Y, Furukawa T, Ito H, Chikamori T, Yamashina A. Brachial-Ankle Pulse Wave Velocity Versus Its Stiffness Index β-Transformed Value as Risk Marker for Cardiovascular Disease. J Am Heart Assoc 2019;8:e013004
  7. Neuen BL, Ohkuma T, Neal B, Matthews DR, de Zeeuw D, Mahaffey KW, Fulcher G, Li Q, Jardine M, Oh R, Heerspink HL, Perkovic V. Effect of Canagliflozin on Renal and Cardiovascular Outcomes across Different Levels of Albuminuria: Data from the CANVAS Program. J Am Soc Nephrol 2019;30:2229-2242
  8. Mukai N, Hata J, Hirakawa Y, Ohara T, Yoshida D, Nakamura U, Kitazono T, Ninomiya T. Trends in the prevalence of type 2 diabetes and prediabetes in a Japanese community, 1988-2012: the Hisayama Study. Diabetol Int 2019;10:198-205
  9. Oshima M, Jun M, Ohkuma T, Toyama T, Wada T, Cooper ME, Hadjadj S, Hamet P, Harrap S, Mancia G, Marre M, Williams B, Chalmers J, Woodward M, Perkovic V. The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study. Diabetologia 2019;62:1988-1997
  10. Rahman F, McEvoy JW, Ohkuma T, Marre M, Hamet P, Harrap S, Mancia G, Rodgers A, Selvin E, Williams B, Muntner P, Chalmers J, Woodward M. Effects of Blood Pressure Lowering on Clinical Outcomes According to Baseline Blood Pressure and Cardiovascular Risk in Patients With Type 2 Diabetes Mellitus. Hypertension 2019;73:1291-1299
  11. Toyama T, van den Broek-Best O, Ohkuma T, Handelsman D, Waite LM, Seibel MJ, Cumming R, Naganathan V, Sherrington C, Hirani V, Wang AY. Associations of Impaired Renal Function With Declines in Muscle Strength and Muscle Function in Older Men: Findings From the CHAMP Study. J Gerontol A Biol Sci Med Sci 2019;74:1812-1820
  12. Toyama T, Neuen BL, Jun M, Ohkuma T, Neal B, Jardine MJ, Heerspink HL, Wong MG, Ninomiya T, Wada T, Perkovic V. Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta-analysis. Diabetes Obes Metab 2019;21:1237-1250
  13. Ohkuma T, Peters SAE, Woodward M. Is there evidence for sex differences in the association between diabetes and cancer? Reply to Dankner R, Boker LK, Freedman LS [letter]. Diabetologia 2019;62:201
  14. 土井康文 (策定委員会 委員),大隈俊明 (策定委員会 システマティックレビュー協力者),中村宇大 (策定委員会 協力者). 糖尿病診療ガイドライン2019 日本糖尿病学会 編・著
受賞歴
  1. 令和元年度 九州大学第二内科同門会功労賞(布井清秀)
  2. 令和元年度 九州大学第二内科同門会奨励賞(大隈俊明)

2018

論文発表
  1. Iwase M, Fujii H, Nakamura U, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Komorita Y, Yoshinari M, Kitazono T. Incidence of diabetic foot ulcer in Japanese patients with type 2 diabetes mellitus: The Fukuoka diabetes registry. Diabetes Res Clin Pract 2018;137:183-189
  2. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T. Impact of Body Weight Loss From Maximum Weight on Fragility Bone Fractures in Japanese Patients With Type 2 Diabetes: The Fukuoka Diabetes Registry. Diabetes Care 2018;41:1061-1067
  3. Komorita Y, Iwase M, Fujii H, Ide H, Ohkuma T, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kitazono T. The serum creatinine to cystatin C ratio predicts bone fracture in patients with type 2 diabetes: The Fukuoka Diabetes Registry. Diabetes Res Clin Pract 2018;146:202-210
  4. Sumi A, Iwase M, Nakamura U, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Kitazono T. Impact of age at menarche on obesity and glycemic control in Japanese patients with type 2 diabetes: Fukuoka Diabetes Registry. J Diabetes Investig 2018;9:1216-1223
  5. Ohkuma T, Peters SAE, Woodward M. Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events. Diabetologia 2018;61:2140-2154
  6. Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A. Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Atherosclerosis 2018;275:141-148
  7. Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A. Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis. Hypertension 2018;71:1030-1038
  8. Jun M, Ohkuma T, Zoungas S, Colagiuri S, Mancia G, Marre M, Matthews D, Poulter N, Williams B, Rodgers A, Perkovic V, Chalmers J, Woodward M. Changes in Albuminuria and the Risk of Major Clinical Outcomes in Diabetes: Results From ADVANCE-ON. Diabetes Care 2018;41:163-170
  9. Neuen BL, Ohkuma T, Neal B, Matthews DR, de Zeeuw D, Mahaffey KW, Fulcher G, Desai M, Li Q, Deng H, Rosenthal N, Jardine MJ, Bakris G, Perkovic V. Cardiovascular and Renal Outcomes With Canagliflozin According to Baseline Kidney Function. Circulation 2018;138:1537-1550
  10. Rådholm K, Chalmers J, Ohkuma T, Peters S, Poulter N, Hamet P, Harrap S, Woodward M. Use of the waist-to-height ratio to predict cardiovascular risk in patients with diabetes: Results from the ADVANCE-ON study. Diabetes Obes Metab 2018;20:1903-1910
  11. Noguchi H, Miyasaka Y, Kaku K, Kurihara K, Nakamura U, Okabe Y, Ohtsuka T, Ishigami K, Nakamura M. Preoperative Muscle Volume Predicts Graft Survival After Pancreas Transplantation: A Retrospective Observational Cohort Study. Transplant Proc 2018;50:1482-1488
  12. Ohkuma T, Woodward M, Chalmers J. Response to Comment on Ohkuma et al. Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial. Diabetes Care 2017;40:1203-1209. Diabetes Care 2018;41:e39
  13. Inoue M, Okamura K, Kitaoka C, Kinoshita F, Namitome R, Nakamura U, Shiota M, Goto K, Ohtsubo T, Matsumura K, Oda Y, Eto M, Kitazono T. Metyrapone-responsive ectopic ACTH-secreting pheochromocytoma with a vicious cycle via a glucocorticoid-driven positive-feedback mechanism. Endocr J 2018;65:755-767
  14. 大城彩香,野原栄,長尾敏彦,中村宇大,北園孝成
    2型糖尿病に合併した尋常性乾癬にリラグルチドが著効した1例
    糖尿病61巻9号600-605, 2018
受賞歴
  1. The John Chalmers Post-Doctoral Award 2018 (大隈俊明)
  2. 平成30年度 日本糖尿病学会九州支部賞(小森田祐二)
  3. 平成30年度 日本骨粗鬆症学会優秀演題賞(小森田祐二)
  4. 平成30年度 九州大学第二内科同門会尾前賞(小森田祐二)

2017

論文発表
  1. Ohkuma T, Iwase M, Fujii H, Ide H, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T. Joint impact of modifiable lifestyle behaviors on glycemic control and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetol Int 2017;8:296-305
  2. Ide H, Iwase M, Fujii H, Ohkuma T, Kaizu S, Jodai T, Kikuchi Y, Idewaki Y, Sumi A, Nakamura U, Kitazono T. Comparison of cystatin C- and creatinine-based estimated glomerular filtration rates for predicting all-cause mortality in Japanese patients with type 2 diabetes: the Fukuoka Diabetes Registry. Clin Exp Nephrol 2017;21:383-390
  3. Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Sumi A, Yoshinari M, Nakamura U, Kang D, Kitazono T. Serum adiponectin predicts fracture risk in individuals with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetologia 2017;60:1922-1930
  4. Sumi A, Nakamura U, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Komorita Y, Yoshinari M, Hirakawa Y, Hirano A, Kubo M, Kitazono T. The gene-treatment interaction of paraoxonase-1 gene polymorphism and statin therapy on insulin secretion in Japanese patients with type 2 diabetes: Fukuoka diabetes registry. BMC Med Genet 2017;18:146
  5. Ohkuma T, Woodward M, Jun M, Muntner P, Hata J, Colagiuri S, Harrap S, Mancia G, Poulter N, Williams B, Rothwell P, Chalmers J. Prognostic Value of Variability in Systolic Blood Pressure Related to Vascular Events and Premature Death in Type 2 Diabetes Mellitus: The ADVANCE-ON Study. Hypertension 2017;70:461-468
  6. Ohkuma T, Tomiyama H, Ninomiya T, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A. Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension. Circ J 2017;81:1540-1542
  7. Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A. Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis. Hypertension 2017;69:1045-1052
  8. Ohkuma T, Jun M, Woodward M, Zoungas S, Cooper ME, Grobbee DE, Hamet P, Mancia G, Williams B, Welsh P, Sattar N, Shaw JE, Rahimi K, Chalmers J. Cardiac Stress and Inflammatory Markers as Predictors of Heart Failure in Patients With Type 2 Diabetes: The ADVANCE Trial. Diabetes Care 2017;40:1203-1209
  9. Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T. Alternative Measures of Hyperglycemia and Risk of Alzheimer’s Disease in the Community: The Hisayama Study. J Clin Endocrinol Metab 2017;102:3002-3010
  10. Date S, Noguchi H, Kaku K, Kurihara K, Miyasaka Y, Okabe Y, Nakamura U, Ohtsuka T, Nakamura M. Laparoscopy-Assisted Spleen-Preserving Distal Pancreatectomy for Living-Donor Pancreas Transplantation. Transplant Proc 2017;49:1133-1137
  11. Kiyohara T, Mizoguchi T, Kuroda J, Wakisaka Y, Irie A, Kitaoka C, Fujisaki K, Nakamura U, Tsuruya K, Kitazono T, Ago T. Repeated Paradoxical Brain Infarctions in a Patient on Self-Managed Home Hemodialysis Using a Long-Term Indwelling Catheter. J Stroke Cerebrovasc Dis 2017;26:e183-e185
  12. 大隈俊明,中村宇大,岩瀬正典
    今、注目される生活習慣 「睡眠」と糖尿病の関係
    糖尿病ライフさかえ 57,6-10,2017
  13. 中村晋,井手均,中村宇大,北園孝成
    抗リウマチ薬により長期間にわたりインスリン必要量が低下した緩徐進行1型糖尿病
    糖尿病60巻1号25-29,2017
受賞歴
  1. 平成29年度(第10回)糖尿病療養指導鈴木万平賞(布井清秀)
  2. 日本高血圧学会 第8回 Hypertension Research Award優秀賞 (大隈俊明)
  3. 日本糖尿病学会 第7回若手研究奨励賞(小森田祐二)
  4. 平成29年度 九州大学第二内科同門会奨励賞(小森田祐二)

2016

論文発表
  1. Ohkuma T, Nakamura U, Iwase M, Ide H, Fujii H, Jodai T, Kaizu S, Kikuchi Y, Idewaki Y, Sumi A, Hirakawa Y, Kitazono T. Effects of smoking and its cessation on creatinine- and cystatin C-based estimated glomerular filtration rates and albuminuria in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Hypertens Res 2016;39:744-751
  2. 藤井裕樹,中村宇大,岩瀬正典
    糖尿病食事療法の総論「食物繊維摂取」
    ホルモンと臨床62,205-209,2016
  3. 大隈俊明,中村宇大,岩瀬正典
    2型糖尿病患者における生活習慣トータルマネージメント 福岡糖尿病患者データベース研究(Fukuoka Diabetes Registry)より
    DM Ensemble 5巻2号 47-51,2016
受賞歴
  1. 平成28年度 九州大学第二内科同門会奨励賞(井手脇康裕)

2015

論文発表
  1. Idewaki Y, Iwase M, Fujii H, Ohkuma T, Ide H, Kaizu S, Jodai T, Kikuchi Y, Hirano A, Nakamura U, Kubo M, Kitazono T. Association of Genetically Determined Aldehyde Dehydrogenase 2 Activity with Diabetic Complications in Relation to Alcohol Consumption in Japanese Patients with Type 2 Diabetes Mellitus: The Fukuoka Diabetes Registry. PLoS One 2015;10:e0143288
  2. Ohkuma T, Iwase M, Fujii H, Kaizu S, Ide H, Jodai T, Kikuchi Y, Idewaki Y, Hirakawa Y, Nakamura U, Kitazono T. Dose- and time-dependent association of smoking and its cessation with glycemic control and insulin resistance in male patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. PLoS One 2015;10:e0122023
  3. Kikuchi Y, Iwase M, Fujii H, Ohkuma T, Kaizu S, Ide H, Jodai T, Idewaki Y, Nakamura U, Kitazono T. Association of severe hypoglycemia with depressive symptoms in patients with type 2 diabetes: the Fukuoka Diabetes Registry. BMJ Open Diabetes Res Care 2015;3:e000063
  4. Ohkuma T, Hirakawa Y, Nakamura U, Kiyohara Y, Kitazono T, Ninomiya T. Association between eating rate and obesity: a systematic review and meta-analysis. Int J Obes (Lond) 2015;39:1589-1596
  5. Mukai N, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y. Association of hemoglobin A1c and glycated albumin with carotid atherosclerosis in community-dwelling Japanese subjects: the Hisayama Study. Cardiovasc Diabetol 2015;14:84
  6. Mizokami T, Fukui T, Imoto H, Fujii H, Sato Y, Nunoi K, Okamura K. Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis. Intern Med 2015;54:421-425
  7. Kaku K, Kitada H, Noguchi H, Kurihara K, Kawanami S, Nakamura U, Tanaka M. Living donor kidney transplantation preceding pancreas transplantation reduces mortality in type 1 diabetics with end-stage renal disease. Transplant Proc 2015;47:733-737
  8. Noguchi H, Kitada H, Kaku K, Kurihara K, Kawanami S, Tsuchimoto A, Masutani K, Nakamura U, Tanaka M. Outcome of renal transplantation in patients with type 2 diabetic nephropathy: a single-center experience. Transplant Proc 2015;47:608-611
  9. 中村宇大
    糖尿病性腎症をどう治療する?「生活管理」
    Jmedmook42 あなたも名医!,日本医事新報社,2015
  10. 松本千紗,中村宇大,北園孝成
    1型糖尿病患者におけるCGMを用いたインスリンデグルデクの有用性の検討
    Diabetes Frontier 26,505-511,2015
  11. 村尾愛,岩瀬正典,冨永丹,大谷博,泊秀史,井手脇康裕,中野昌弘,城崎洋,中村宇大,北園孝成
    Plummer病を合併した2型糖尿病ケトアシドーシスの1例
    糖尿病58巻9号 681-687,2015
受賞歴
  1. 平成27年度 九州大学第二内科同門会奨励賞(菊池洋平)

2014

論文発表
  1. Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T. U-shaped association of sleep duration with metabolic syndrome and insulin resistance in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Metabolism 2014;63:484-491
  2. Kaizu S, Kishimoto H, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai T, Kikuchi Y, Idewaki Y, Hirakawa Y, Nakamura U, Kitazono T. Impact of leisure-time physical activity on glycemic control and cardiovascular risk factors in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. PLoS One 2014;9:e98768
  3. Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y. Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: The Hisayama Study. J Diabetes Investig 2014;5:162-169
  4. Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y. Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study. Cardiovasc Diabetol 2014;13:45
受賞歴
  1. 平成26年度 日本糖尿病学会九州支部賞 (大隈俊明)
  2. 平成26年度 九州大学第二内科同門会奨励賞(藤井裕樹)

2013

論文発表
  1. Fujii H, Iwase M, Ohkuma T, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Joudai T, Hirakawa Y, Uchida K, Sasaki S, Nakamura U, Kitazono T. Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry. Nutr J 2013;12:159
  2. Ohkuma T, Fujii H, Iwase M, Kikuchi Y, Ogata S, Idewaki Y, Ide H, Doi Y, Hirakawa Y, Nakamura U, Kitazono T. Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka Diabetes Registry. Diabetes Care 2013;36:611-617
  3. Ohkuma T, Fujii H, Iwase M, Ogata-Kaizu S, Ide H, Kikuchi Y, Idewaki Y, Jodai T, Hirakawa Y, Nakamura U, Kitazono T. Association between sleep duration and urinary albumin excretion in patients with type 2 diabetes: the Fukuoka diabetes registry. PLoS One 2013;8:e78968
  4. Ohkuma T, Fujii H, Iwase M, Kikuchi Y, Ogata S, Idewaki Y, Ide H, Doi Y, Hirakawa Y, Mukai N, Ninomiya T, Uchida K, Nakamura U, Sasaki S, Kiyohara Y, Kitazono T. Impact of eating rate on obesity and cardiovascular risk factors according to glucose tolerance status: the Fukuoka Diabetes Registry and the Hisayama Study. Diabetologia 2013;56:70-77
  5. Yamada S, Tokumoto M, Ohkuma T, Kansui Y, Wakisaka Y, Uchizono Y, Tsuruya K, Kitazono T, Ooboshi H. Slowly progressive and painless thoracic aortic dissection presenting with a persistent Fever in an elderly patient: the usefulness of combined measurement of biochemical parameters. Case Rep Med 2013;2013:498129
  6. 岩瀬正典,北田秀久,岡部安博,杉谷篤,田中雅夫
    膵臓移植適応患者65例の長期予後の検討
    糖尿病56巻5号 285-291,2013
受賞歴
  1. 第1回 Kyushu Diabetes Research Conference 最優秀奨励賞 (大隈俊明)
  2. 平成25年度 九州大学第二内科同門会奨励賞(大隈俊明)
  3. 平成25年度 九州大学第二内科同門会奨励賞(平川洋一郎)